Journal:

Article Title: A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase ( PTPN22 ) Is Associated with Rheumatoid Arthritis

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Figure Lengend Snippet: RNA Expression Levels of PTPN22 in Purified Normal Cell Populations, Tissues, and Transformed Cell Lines, Expressed as a Fold Change Relative to the Average of All Normal Tissues (Excluding Tumor Cell Lines and Purified Hematopoietic Cells) [Note]

Article Snippet: Table A1 Cell/Tissue Type Source Fold Change a Normal cells: NK cells AllCells 25.14 Neutrophils AllCells 24.82 CD8+ T cells AllCells 12.26 Bone marrow Clontech 10.41 Monocytes AllCells 8.42 PBMCs AllCells 7.86 Dendritic cells AllCells 7.81 Pan T cells AllCells 6.85 CD4+ T cells AllCells 5.21 B cells AllCells 5.01 Tissues: Adipose BioChain −2.21 Adrenal gland Clontech −4.98 Bladder Clontech −2.64 Whole brain Clontech −14.27 Brain Clontech −37.66 Brain (fetal) Clontech −12.84 Breast Stratagene −1.68 Breast BioChain −1.98 Breast Clontech −5.35 Breast (mammary gland) Clontech −1.82 Cervix Ambion ND Esophagus BioChain −3.61 Heart Clontech −6.73 Heart (aorta) Clontech −1.63 Heart (diseased) Clontech −17.65 Heart (diseased, post-infarction) Clontech −8.67 Heart (pericardium) BioChain −1.56 Heart (fetal) Clontech −22.25 Intestine (large) Stratagene 2.99 Intestine (large, tumor) Stratagene −1.89 Intestine (small) Clontech −1.62 Intestine (small, ileum diseased) Stratagene 2.54 Kidney Clontech −10.69 Kidney (fetal) Clontech −15.79 Liver Clontech −2.59 Liver (fetal) Clontech −4.96 Lung Stratagene 4.18 Lung (tumor) Clontech −1.07 Muscle (skeletal) Clontech −17.45 Muscle (skeletal) Ambion −23.81 Ovary Stratagene −1.15 Ovary (tumor) Clontech −8.28 Pancreas BioChain −3.34 Placenta Clontech −5.43 Prostate Stratagene −1.61 Prostate Clontech −132.45 Salivary gland Clontech −17.23 Spinal cord Clontech −4.75 Spleen (fetal) Clontech −1.13 Stomach BioChain −2.16 Stomach (tumor) Clontech −1.87 Testis Clontech −3.08 Thymus Clontech 1.29 Thymus (fetal) Clontech 4.75 Thyroid (female) Stratagene 3.61 Thyroid Stratagene 3.41 Thyroid Clontech −4.13 Tonsil Clontech −1.17 Trachae Clontech −2.19 Umbilical cord (fetal) BioChain −1.37 Uterus Clontech −8.95 Transformed cell lines: Jurkat Ambion 9.45 HL60 Ambion 8.66 K562 Ambion 1.28 K562 (PMA treated) Stratagene −1.28 K562 Stratagene −4.33 PC3 (prostate carcinoma) Ambion −15.1 HeLa S3 Clontech −24.81 A431 (epidermal carcinoma) Ambion ND HeLa S3 Ambion ND Open in a separate window Note.— ND = not detected. a Expression of the PTPN22 major splice variant was determined by kinetic RT-PCR analysis.

Techniques: RNA Expression, Purification, Transformation Assay